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Why do anti-tumor necrosis factor antibodies work in Crohn's disease?

Bruce E Sands1

  • 1Gastrointestinal Unit and MGH Inflammatory Bowel Disease Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Reviews in Gastroenterological Disorders
|December 8, 2004
PubMed

Anti-tumor necrosis factor (TNF) antibodies are powerful therapeutic agents for the treatment of Crohn's disease. TNF has diverse proinflammatory effects within the intestinal mucosa and is a pivotal cytokine in the inflammatory cascade. Although anti-TNF antibodies exert a variety of anti-inflammatory effects by neutralizing the cytokine, these agents vary in their efficacy. Recent data suggest that the ability to bind transmembrane TNF is a key property necessary for efficacy. Transmembrane binding of TNF effects apoptosis of T cells, thereby alleviating a fundamental defect in Crohn's disease in the regulation of T cell populations.

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