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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Anthropometry, metabolic control, and thyroid autoimmunity in type 1 diabetes with celiac disease: A multicenter

Stefan Kaspers1, Olga Kordonouri, Edith Schober

  • 1University Children's Hospital, Essen, Germany. S.Kaspers@gmx.de

The Journal of Pediatrics
|December 8, 2004
PubMed

Insights

Children with type 1 diabetes (T1D) and celiac disease (CD) experienced earlier diabetes onset and reduced growth. This highlights the importance of screening for CD in T1D patients.

Area of Science:

  • Pediatric Endocrinology
  • Autoimmune Diseases
  • Gastroenterology

Background:

  • Type 1 diabetes (T1D) and celiac disease (CD) are autoimmune conditions that can co-occur in children.
  • The impact of CD on growth and metabolic control in pediatric T1D patients is not fully understood.
  • Early identification and management of co-existing conditions are crucial for optimal patient outcomes.

Purpose of the Study:

  • To investigate the influence of celiac disease (CD) on growth and metabolic control in a nationwide cohort of children and adolescents with type 1 diabetes (T1D).

Main Methods:

  • Analysis of data from 19,796 pediatric patients with T1D from the German DPV-database.
  • Assessment of CD occurrence through serological markers and small-bowel biopsy confirmation.
  • Comparison of growth parameters (height-SDS, BMI-SDS) and metabolic control (HbA1c) between T1D patients with and without CD.

Main Results:

  • Celiac disease antibodies were found in 6.7% of T1D patients, with biopsy-confirmed CD in 0.6%.
  • T1D patients with CD were diagnosed at a younger age and exhibited significantly lower height-SDS at onset and during follow-up.
  • Female subjects showed a higher predisposition for both T1D and CD. Thyroid disease was more prevalent in the T1D with CD group.

Conclusions:

  • Celiac disease is associated with earlier diabetes onset and impaired growth in pediatric patients with type 1 diabetes.
  • These findings underscore the clinical significance of screening for celiac disease in children and adolescents diagnosed with autoimmune diabetes.
  • Integrated management strategies are essential for addressing the complexities of co-existing T1D and CD.
Abstract

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