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Updated: Aug 20, 2026
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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic
Terrie E Inder1, Rod W Hunt, Colin J Morley
1Division of Newborn Services, Royal Women's Hospital, Neonatal Neurology, Royal Children's Hospital, Melbourne, Australia. terrie.inder@rch.org.au
The Journal of Pediatrics
|December 8, 2004
Abstract:
Twenty-six infants with hypoxic-ischemic encephalopathy (HIE) were randomized to normothermia or to systemic hypothermia. The hypothermia group had less cortical gray matter signal abnormality on magnetic resonance imaging (MRI) (1/12 vs 7/14 infants in the normothermic group; P = .036), which may indicate differing regional benefit from systemic hypothermia.
