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Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C
Akinori Kasahara1, Atsushi Hiraide, Naruya Tomita
1Department of General Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-Oka, 565-0871, Suita, Japan.
Abstract:
Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C. Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon. Therefore, we conclude that chronic hepatitis C patients, especially people with darkly pigmented skin, need to be closely monitored for ophthalmologic complications, by periodic check-up of the optic fundi, for a prolonged period, during interferon treatment.
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