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Related Experiment Videos

Herpes simplex uveitis.

Carmen Santos1

  • 1Department of Ophthalmology University of Puerto Rico School of Medicine.

Boletin De La Asociacion Medica De Puerto Rico
|December 8, 2004
PubMed
Summary
This summary is machine-generated.

Herpes simplex virus (HSV) uveitis without corneal disease is more common than previously believed. This presentation can lead to delayed diagnosis, severe glaucoma, and significant vision loss.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Virology

Background:

  • Herpes simplex virus (HSV) ocular disease typically involves corneal stromal disease.
  • Herpetic uveitis without keratitis is considered rare and often misdiagnosed.
  • This condition is frequently misattributed to varicella zoster virus (VZV).

Observation:

  • Seven patients with anterior uveitis and sectoral iris atrophy, but no keratitis, were identified.
  • Four patients tested positive for HSV via aqueous polymerase chain reaction (PCR).
  • One patient presented with bilateral ocular involvement.

Findings:

  • Five patients had no prior history of corneal disease.
  • Two patients had a history of resolved dendritic keratitis.

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  • Six patients developed secondary glaucoma, with five requiring surgery.
  • Implications:

    • Uveitis without corneal involvement may be an underrecognized manifestation of HSV ocular disease.
    • Delayed diagnosis due to lack of keratitis can negatively impact visual outcomes.
    • Associated glaucoma is a severe complication that can lead to rapid vision loss.