Related Experiment Video
Updated: Aug 20, 2026

Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins
Published on: June 20, 2019
The enzymes of oxalate metabolism: unexpected structures and mechanisms
Drazenka Svedruzić1, Stefán Jónsson, Cory G Toyota
1Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
Abstract:
Oxalate degrading enzymes have a number of potential applications, including medical diagnosis and treatments for hyperoxaluria and other oxalate-related diseases, the production of transgenic plants for human consumption, and bioremediation of the environment. This review seeks to provide a brief overview of current knowledge regarding the major classes of enzymes and related proteins that are employed in plants, fungi, and bacteria to convert oxalate into CO(2) and/or formate. Not only do these enzymes employ intriguing chemical strategies for cleaving the chemically unreactive C-C bond in oxalate, but they also offer the prospect of providing new insights into the molecular processes that underpin the evolution of biological catalysts.
Related Concept Videos
Peroxisomes
Peroxisomes
Peroxisomes
Phase I Oxidative Reactions: Overview
Enzymes
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
