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Updated: Aug 20, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
Published on: March 17, 2014
Regulation of dendritic growth by calcium and neurotrophin signaling
Paul A Dijkhuizen1, Anirvan Ghosh
1Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands.
Abstract:
The development of cortical dendrites is regulated by both activity-dependent and activity-independent signaling. Activity-dependent dendritic growth involves calcium-dependent gene expression. Both CREB and CREST are transactivators that contribute to calcium-dependent dendritic growth. Dendritic development is also regulated by extracellular factors such as neurotrophins. Neurotrophin-dependent dendritic growth is mediated by the MAP kinase and PI 3-kinase pathways. Selective responsiveness to activity cues and neurotrophins may contribute to morphological diversity in the nervous system.
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