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Updated: Aug 20, 2026

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
Published on: February 8, 2020
Molecular substrates of plasticity in the developing visual cortex
Sharif A Taha1, Michael P Stryker
1Department of Neurology, University of California at San Francisco, San Francisco, CA 94143, USA.
Abstract:
Ocular dominance plasticity may be the paradigmatic in vivo model of activity-dependent plasticity. More than four decades of intense research has delineated the network-level rules that govern synaptic change in this model. The recent characterization of a murine model for ocular dominance plasticity has facilitated rapid progress on a new front, extending our understanding of the molecular mechanisms underlying ocular dominance plasticity. In this review, we highlight recent advances in this research effort, focusing in particular on signaling pathways mediating shifts in ocular dominance, and mechanisms underlying the timing of the critical period.
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