Related Experiment Video
Updated: Aug 20, 2026

Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells
Published on: December 22, 2010
Interactions of lipid monolayers with the natural biopolymer hyaluronic acid
R Ionov1, A El-Abed, M Goldmann
1LNPC, Université René Descartes, 45, rue des Saints Pères, 75270 Paris Cedex 06, France. r_ionov@hotmail.com
Abstract:
The interaction of the natural mucopolysaccharide hyaluronic acid with different lipids, present in the natural membranes, was studied at the lipid/water interface using thermodynamic methods and X-ray diffraction. The results show that this biopolymer modifies the properties and the structure of the lipid monolayer. The two-dimensional crystalline lattice and domain structure of the charged octadecylamine monolayer are strongly disturbed by the hyaluronic acid, the monolayer compressibility increases and the monolayer collapse pressure drops down. In addition, the presence of charged lipid interfaces influences the structural organisation of the hyaluronic acid at the membrane/water interfaces. The impacts of these results on the structural organisation at the membrane interface are discussed.
Related Concept Videos
Asymmetric Lipid Bilayer
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Fluid Mosaic Model
Fluid Mosaic Model
Mechanisms of Membrane Domain Formation
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...

