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Related Experiment Videos

Intestinal lymphatic vessels release endothelial-dependent vasodilators.

H G Bohlen1, J M Lash

  • 1Department of Physiology and Biophysics, Indiana University Medical School, Indianapolis 54223.

The American Journal of Physiology
|March 1, 1992
PubMed
Summary

Lymphatic endothelial cells release vasoactive agents that constrict lymphatic vessels and dilate nearby arterioles. This study investigated the mechanisms behind these lymphatic-mediated vascular effects.

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Area of Science:

  • Physiology
  • Vascular Biology
  • Lymphatic System Research

Background:

  • The role of lymphatic endothelial cells in regulating microvascular function is not fully understood.
  • Vasoactive agents' effects on lymphatic vessels and surrounding arterioles require further investigation.

Purpose of the Study:

  • To determine if lymphatic endothelial cells release vasoactive agents.
  • To investigate the impact of these agents on lymphatic vessel diameter and nearby arteriolar tone.

Main Methods:

  • Microiontophoresis of acetylcholine (ACh) and bradykinin (BK) on rat intestinal lymphatic and arteriolar walls.
  • Assessment of lymphatic and arteriolar diameter changes in response to drug application.
  • Evaluation of NG-monomethyl-L-arginine's effect on lymphatic-mediated responses.

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Main Results:

  • Acetylcholine and bradykinin constricted spontaneously active lymphatic vessels but not quiescent ones.
  • Both agents caused significant vasodilation when applied to arterioles.
  • Lymphatic application of ACh and BK induced arteriolar dilation, mimicking direct application.
  • NG-monomethyl-L-arginine blocked ACh-induced lymphatic-mediated responses.

Conclusions:

  • Lymphatic endothelial cells release agents that constrict lymphatic vessels.
  • These cells also release factors that dilate adjacent arterioles.
  • The findings support the hypothesis of lymphatic endothelial cells influencing local vascular tone.