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Adipose tissue concentrations of p,p'-DDE and the risk for endometrial cancer
Lennart Hardell1, Bert van Bavel, Gunilla Lindström
1Department of Oncology, University Hospital, SE-701 85 Orebro, Sweden. lennart.hardell@orebol.se
Objective:
To evaluate in a case-control study possible risk of endometrial cancer associated with environmental endocrine disruptors.
Methods:
We analyzed the adipose tissue concentrations of polychlorinated biphenyls, hexachlorobenzene (HCB), p,p'-dichlorodiphenyl-dichloroethylene (p,p'-DDE), chlordanes, and polybrominated biphenyls in 76 cases with endometrial cancer and 39 controls with benign endometrial hyperplasia.
Results:
For the different chemicals, odds ratios (ORs) and 95% confidence intervals (CI) were close to unity taking the median concentration among the controls as cutoff value. However, for p,p'-DDE OR = 1.9, 95% CI = 0.8-4.8 was obtained. Additional estrogen replacement therapy yielded in this category OR = 2.3, 95% CI = 0.6-8.6.
Conclusion:
The results suggest an interaction between p,p'-DDE and estrogen replacement drugs in the etiology of endometrial cancer, although no significant associations were found.
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