Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microinvasive Paget's disease.

Thomas Ewing1, John Sawicki, Giuseppe Ciaravino

  • 1Department of Obstetrics and Gynecology, Kaiser Permanente Medical Center, 280 W. MacArthur Boulevard, Oakland, CA 94611, USA. Thomas.Ewing@kp.org

Gynecologic Oncology
|December 8, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stenotrophomonas maltophilia Bloodstream Infection Outbreak in Acute Care Hospital, California, USA, 2022-2023<sup>1</sup>.

Emerging infectious diseases·2026
Same author

Neuroinvasive <i>Bacillus cereus</i> Infection in Immunocompromised Hosts: Epidemiologic Investigation of 5 Patients With Acute Myeloid Leukemia.

Open forum infectious diseases·2024
Same author

Extensively Drug-Resistant Pseudomonas aeruginosa Outbreak Associated With Artificial Tears.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2024
Same author

Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline.

American journal of respiratory and critical care medicine·2022
Same author

A 57-year-old man with rapidly progressive pulmonary hypertension.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2021
Same author

Streamlining genetic testing for women with ovarian cancer in a Northern California health care system.

Gynecologic oncology·2020
Same journal

Toward precision prognosis: Predicting recurrence-free survival in high-grade serous ovarian cancer patients using multi-time point clinical and computed tomography radiomics data.

Gynecologic oncology·2026
Same journal

Adjunctive sodium-glucose cotransporter 2 (SGLT2) inhibitors with progestins and endometrial cancer risk in benign uterine diseases and hyperplasia.

Gynecologic oncology·2026
Same journal

Updated patient-reported outcomes and the effect of disease progression on health-related quality of life in the PRIMA/ENGOT-OV26/GOG-3012 trial of niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer.

Gynecologic oncology·2026
Same journal

PRO-PLATINUM: A randomized, double-blind, placebo controlled study to investigate the efficacy of a probiotic intervention on the gut and vaginal microbiome of ovarian cancer patients undergoing treatment with platinum chemotherapy.

Gynecologic oncology·2026
Same journal

A second chance for the second look: Feasibility of laparoscopic HIPEC at the conclusion of upfront treatment for epithelial ovarian cancer.

Gynecologic oncology·2026
Same journal

Prognostic impact of time to first recurrence in low-grade serous ovarian carcinoma: A multicentric retrospective study from the French TMRG network.

Gynecologic oncology·2026
See all related articles

Sentinel lymph node (SLN) analysis may be a valid method for evaluating microinvasive Paget's disease of the vulva. This approach helps determine the need for further treatment in rare cases.

Area of Science:

  • Gynecologic Oncology
  • Surgical Pathology
  • Vulvar Diseases

Background:

  • Microinvasive squamous cell carcinoma of the vulva (< or =1 mm stromal invasion) is treated with wide local resection.
  • The applicability of these microinvasion criteria to Paget's disease of the vulva is uncertain due to its rarity.

Observation:

  • Three cases of microinvasive Paget's disease were evaluated using sentinel lymph node (SLN) analysis.
  • Two patients with negative SLNs showed no recurrence of invasive or metastatic disease.
  • One patient with a positive SLN (the sole positive node) underwent bilateral groin lymph node dissection.

Findings:

  • Sentinel lymph node biopsy appears to be a potentially valid method for staging microinvasive Paget's disease.
  • SLN status may correlate with the risk of recurrence and the need for further nodal treatment.

Related Experiment Videos

Implications:

  • SLN evaluation could refine treatment strategies for microinvasive Paget's disease of the vulva.
  • This technique may help avoid extensive lymph node dissection in select patients.
  • Further research is warranted to confirm the utility of SLN analysis in this rare condition.