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Updated: Aug 20, 2026

Laparoscopic Extracorporeal Knot-Tying for Uterine Vessel Occlusion during Hysterectomy with Cervical Cerclage in Large Uteri
Published on: September 12, 2025
Levonorgestrel-releasing intrauterine system (LNG-IUS) as a therapy for endometrial carcinoma
Theodoros Giannopoulos1, Simon Butler-Manuel, Anil Tailor
1Department of Gynaecological Oncology, Royal Surrey County Hospital, Guildford, UK. tgiuk@yahoo.com
Background:
Primary treatment of endometrial cancer with progestogens is reserved for adjuvant or palliative treatment, although with unproven efficacy.
Case:
We present a case of early endometrial cancer where a combination of oral progestogens and levonorgestrel releasing intrauterine system (Mirena) was used as a primary treatment, as the standard surgical treatment was deemed to carry an unacceptable mortality risk.
Conclusion:
Our treatment has resulted in reversion of the cancerous endometrial histological changes. This is encouraging, but obviously more cases and lengthier follow-up time are required in order to obtain more valid conclusions.
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