Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ink4a/Arf links senescence and aging.

Norman E Sharpless1

  • 1Departments of Medicine and Genetics, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA. nes@med.unc.edu

Experimental Gerontology
|December 8, 2004
PubMed
Summary

The INK4a/ARF locus suppresses tumors by regulating cell growth and senescence. Its expression also drives mammalian aging by limiting stem cell regeneration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Threat to Evidence-Based Vaccine Policy and Public Health Security at the FDA.

The New England journal of medicine·2025
Same author

Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

Cancer cell·2024
Same author

Bridging the Gap in Cancer Clinical Trial Funding.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2024
Same author

Expression of Concern: Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma.

Cancer discovery·2024
Same author

Author Correction: An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.

Nature medicine·2024
Same author

The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2023

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Gerontology

Background:

  • The INK4a/ARF locus produces tumor suppressor proteins p16INK4a and ARF.
  • These proteins regulate the retinoblastoma (RB) and p53 pathways, respectively.
  • Both proteins are crucial for inducing cellular senescence and preventing cancer.

Purpose of the Study:

  • To investigate the dual role of the INK4a/ARF locus in cancer suppression and aging.
  • To explore how INK4a/ARF-induced senescence impacts tissue regeneration and stem cell function.

Main Methods:

  • Analysis of genetic data on tumor suppressor activity.
  • Examination of murine models to study in vivo senescence.
  • Correlation of INK4a/ARF expression with aging phenotypes.

Main Results:

  • p16INK4a and ARF exhibit significant in vivo tumor suppressor activity.
  • INK4a/ARF proteins are induced in most cultured cells, mediating senescence.
  • In vivo senescence driven by INK4a/ARF leads to reduced regenerative capacity and stem cell decline.

Conclusions:

  • The INK4a/ARF locus acts as a critical tumor suppressor.
  • Expression of the INK4a/ARF locus is a key effector of mammalian aging.
  • This locus links cancer prevention to the aging process by affecting stem cell reserves.

Related Experiment Videos