Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IGF-1 signaling and aging.

Martin Holzenberger1, Laurent Kappeler, Carlos De Magalhaes Filho

  • 1Inserm U515, Hôpital Saint-Antoine, 75571 Paris 12, France. holzenberger@st-antoine.inserm.fr

Experimental Gerontology
|December 8, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulation of HDL dysfunctionality by phosphatidylethanolamine links poly-unsaturated fatty acids with atherosclerotic cardiovascular diseases.

Molecular metabolism·2025
Same author

Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition.

iScience·2024
Same author

Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland.

eLife·2024
Same author

The developmental basis for scaling of mammalian tooth size.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Stimulation of GHRH Neuron Axon Growth by Leptin and Impact of Nutrition during Suckling in Mice.

Nutrients·2023
Same author

Role of Adipose Tissue microRNAs in the Onset of Metabolic Diseases and Implications in the Context of the DOHaD.

Cells·2022

Animal lifespan is regulated by endocrine factors, with the hypothalamus potentially integrating metabolic and hormonal signals. Research across species reveals a complex interplay influencing growth, fertility, and longevity.

Area of Science:

  • Genetics and Aging Research
  • Endocrinology
  • Comparative Biology

Background:

  • Aging is influenced by genetic and environmental factors, with model organisms providing insights into lifespan regulation.
  • Hormonal pathways, including growth hormone (GH) and insulin-like growth factor 1 (IGF-1), are implicated in aging processes.
  • Previous studies suggest dissociation between growth, fertility, and longevity phenotypes in certain genetic mutants.

Purpose of the Study:

  • To explore the endocrine regulation of animal lifespan by comparing various genetic models.
  • To investigate the role of the nervous system and hypothalamus in lifespan regulation.
  • To synthesize findings from diverse model organisms to understand converging mechanisms of aging.

Main Methods:

  • Comparative analysis of mutant phenotypes (calorie restriction, GHRH-R, Pit-1, GH receptor, IGF-1 receptor, p66Shc).

Related Experiment Videos

  • Review of studies in Caenorhabditis elegans and Drosophila melanogaster on lifespan regulation.
  • Examination of mouse models with specific gene knockouts (e.g., insulin receptor in adipose tissue).

    • Main Results:

    • Phenotypes related to growth, fertility, and longevity can be dissociated in certain genetic mutants.
    • Lifespan regulation can occur in a non-cell-autonomous manner, with the nervous system playing a key role (C. elegans).
    • Endocrine regulation of lifespan is supported by findings in insects (Drosophila) and mammals (mice), particularly involving insulin signaling.

    Conclusions:

    • Converging evidence from diverse model organisms suggests that animal lifespan is subject to endocrine regulation.
    • The hypothalamus may serve as a central hub integrating metabolic and hormonal signals for lifespan regulation.
    • Understanding these endocrine pathways is crucial for aging research and potential interventions.