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Updated: Jul 22, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
Published on: March 22, 2012
Lipid rafts and the initiation of T cell receptor signaling
Hai-Tao He1, Annemarie Lellouch, Didier Marguet
1Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Parc Scientifique de Luminy, Case 906, 13288 Marseille Cedex 9, France. he@ciml.univ-mrs.fr
Abstract:
The role of lipid rafts in T cell signalling has recently been extensively studied and hotly debated. In this review we wish to present recent advances in the study of lipid rafts with regards to the initiation of TCR signal transduction. We also wish to clarify some common misconceptions regarding certain models and experimental methods reported in the literature. Based on the relevant data supporting the functional importance of lipid rafts in early TCR mediated signalling events, we propose a model for TCR signal initiation involving a "TCR signalosome" organized in a specific raft subset, which is highly dynamic and evolving upon TCR activation.
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