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Updated: Aug 20, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
Published on: March 22, 2012
Multi-chain immune recognition receptors: spatial organization and signal transduction
1Department of Pathology, S2-302, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Alexander.Sigalov@umassmed.edu
Abstract:
Multi-chain immune recognition receptors (MIRRs) on T cells, B cells, mast cells and basophils function to transduce signals leading to a variety of biologic responses. These receptors are complexes formed by the association of immunoglobulin-like recognition subunits and signal-transducing subunits. How extracellular ligand binding initiates intracellular signal transduction processes is not clear, and little structural or biochemical information is available for the spatiotemporal organization of this key event in immune cell activation. Here, the current progress in studying this important aspect of cellular signaling is reviewed.
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