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Cord blood banking.

Ruth Warwick1, Sue Armitage

  • 1London Cord Blood Bank, National Blood Service, Edgware, Middlesex HA8 9BD, UK.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|December 8, 2004
PubMed
Summary

Cord blood (CB) is a rich source of hematopoietic stem cells (HSC) for transplantation, offering a safe,

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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Transplantation Medicine

Background:

  • Cord blood (CB) is rich in hematopoietic stem cells (HSC).
  • CB transplantation restores hemopoiesis in patients with various disorders.
  • CB is a viable alternative to bone marrow transplantation.

Purpose of the Study:

  • To highlight the significance of cord blood as a source of HSC.
  • To discuss the collection, processing, and storage of cord blood.
  • To compare cord blood transplantation with bone marrow transplantation.

Main Methods:

  • Collection of cord blood from vaginal deliveries and caesarean sections.
  • Processing to remove plasma and red cells.
  • Cryopreservation, HLA-typing, and storage for 'off-the-shelf' availability.

Main Results:

  • CB transplantation is effective in pediatric and adult settings.
  • CB offers a lower risk of viral infections and graft-versus-host disease (GvHD).
  • EU regulations ensure safety and efficacy in cord blood banking.

Conclusions:

  • Cord blood is a valuable, readily available resource for transplantation.
  • Ongoing research aims to improve cord blood transplant outcomes.
  • Non-hematopoietic stem cell applications of CB are currently speculative.

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