Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Curcumin for malaria therapy.

Raju C Reddy1, Palakkodu G Vatsala, Venkateshwar G Keshamouni

  • 1Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI 48109-0360, USA.

Biochemical and Biophysical Research Communications
|December 8, 2004
PubMed
Summary

Curcumin, derived from turmeric, shows promise as an antimalarial treatment. It effectively inhibits malaria parasite growth in vitro and in vivo, significantly improving survival rates in infected mice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

E2A selectively regulates TGF-β-induced apoptosis in KRAS-mutant non-small cell lung cancer.

Molecular oncology·2026
Same author

Discovery and Development of a Small-Molecule Inhibitor Targeting the GAS41 YEATS Domain in Nonsmall Cell Lung Cancer.

Journal of medicinal chemistry·2025
Same author

Lysozyme Amyloid for Synthetic RNA Delivery.

Pharmaceutics·2025
Same author

Cell adhesion molecule-1 is a promising target for chimeric antigen receptors in lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands)·2025
Same author

A preliminary investigation into the activity and toxicity of an amyloid-based Emodin formulation.

Toxicon : official journal of the International Society on Toxinology·2025
Same author

Synthetic transcription factors establish the function of nine amino acid transactivation domains of Komagataella phaffii Mxr1.

The Journal of biological chemistry·2025

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Natural Product Chemistry

Background:

  • Malaria remains a significant global health challenge, necessitating novel therapeutic strategies.
  • Existing antimalarial treatments face challenges like drug resistance and accessibility.
  • There is an urgent need for new, cost-effective antimalarial drugs.

Purpose of the Study:

  • To investigate the antimalarial activity of curcumin, a compound found in turmeric.
  • To evaluate curcumin's efficacy against chloroquine-resistant Plasmodium falciparum.
  • To assess the therapeutic potential of curcumin in a murine model of malaria.

Main Methods:

  • In vitro testing of curcumin against chloroquine-resistant Plasmodium falciparum cultures.
  • Determination of the inhibitory concentration 50 (IC50) of curcumin.

Related Experiment Videos

  • In vivo studies involving oral administration of curcumin to Plasmodium berghei-infected mice.
  • Monitoring of blood parasitemia and survival rates in treated mice.

    • Main Results:

    • Curcumin demonstrated dose-dependent inhibition of chloroquine-resistant Plasmodium falciparum growth in vitro, with an IC50 of approximately 5 microM.
    • Oral administration of curcumin in mice led to an 80-90% reduction in blood parasitemia.
    • Curcumin treatment significantly enhanced the survival of malaria-infected mice.

    Conclusions:

    • Curcumin exhibits significant antimalarial properties against Plasmodium falciparum.
    • Curcumin demonstrates therapeutic efficacy in a mouse model of malaria.
    • Curcumin represents a potential novel and accessible treatment option for malaria.