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Pediatric Animal Model of Extracorporeal Cardiopulmonary Resuscitation After Prolonged Circulatory Arrest
Published on: May 26, 2023
Characteristics and outcome of cardiorespiratory arrest in children
Jesús López-Herce1, Cristina García, Pedro Domínguez
1Arzobispo Morcillo 28029 Madrid, Spain. pielvi@ya.com
Insights
Pediatric cardio-respiratory arrest in Spain has a high mortality rate, with survival significantly better after respiratory arrest compared to cardiac arrest. Longer cardiopulmonary resuscitation times indicate higher mortality risk in children.
Area of Science:
- Pediatric Emergency Medicine
- Cardiology
- Resuscitation Science
Background:
- Cardio-respiratory arrest (CRA) in children presents unique challenges in diagnosis and management.
- Understanding current outcomes and characteristics of pediatric CRA is crucial for improving survival rates.
- Previous studies highlight variations in pediatric CRA based on arrest type and location.
Purpose of the Study:
- To analyze the current characteristics and outcomes of pediatric cardio-respiratory arrest in Spain.
- To identify key factors influencing survival rates in children experiencing CRA.
Main Methods:
- An 18-month prospective, multicenter study.
- Inclusion of 283 children (7 days to 17 years) experiencing out-of-hospital or in-hospital CRA.
- Data collection followed the Utstein style, analyzing initial and 1-year survival.
Main Results:
- A total of 311 CRA episodes were analyzed (70 respiratory, 241 cardiac).
- Accidents were the leading cause of out-of-hospital CRA (40%), while cardiac disease led in-hospital CRA (31%).
- Initial survival was 60.2%, with a 1-year survival of 33.2%. Survival was higher for respiratory arrest (70%) than cardiac arrest (21.1%).
- Cardiopulmonary resuscitation duration exceeding 20 minutes was the strongest predictor of mortality (OR: 10.35).
Conclusions:
- Pediatric cardio-respiratory arrest in Spain continues to have a high mortality rate.
- Survival outcomes are significantly better for children experiencing respiratory arrest compared to cardiac arrest.
- The duration of cardiopulmonary resuscitation is the most critical indicator of mortality in pediatric CRA.
Objective:
To analyse the present day characteristics and outcome of cardio-respiratory arrest in children in Spain.
Design:
An 18-month prospective, multicentre study analysing out-of-hospital and in-hospital cardio-respiratory arrest in children.
Patients And Methods:
Two hundred and eighty-three children between 7 days and 17 years of age with cardio-respiratory arrest. Data were recorded according to the Utstein style. The outcome variables were the sustained return of spontaneous circulation (initial survival), and survival at 1 year (final survival). Three hundred and eleven cardio-respiratory arrest episodes, composed of 70 respiratory arrests and 241 cardiac arrests in 283 children were studied. Accidents were the most frequent cause of out-of-hospital arrest (40%), and cardiac disease was the leading cause (31%) of in-hospital arrest. Initial survival was 60.2% and 1 year survival was 33.2%. The final survival was higher in patients with respiratory arrest (70%) than in patients with cardiac arrest (21.1%) (P <0.0001). Although many individual factors correlated with mortality, multivariate logistic regression revealed that the best indicator of mortality was a duration of cardiopulmonary resuscitation of over 20 min (odds ratio: 10.35; 95% CI 4.59-23.32).
Conclusions:
In Spain, the present mortality from cardio-respiratory arrest in children remains high. Survival after respiratory arrest is significantly higher than after cardiac arrest. The duration of cardiopulmonary resuscitation attempt is the best indicator of mortality of cardio-respiratory arrest in children.
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