Related Experiment Video
Updated: Aug 20, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Anxiety and depression in children with epilepsy and their mothers
Orhan Baki1, Ayten Erdogan, Orhun Kantarci
1Department of Neurology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Insights
Children with epilepsy show higher rates of depression but not anxiety compared to healthy peers. This finding is independent of maternal mental health status.
Area of Science:
- Pediatric Neurology
- Child Psychiatry
- Clinical Psychology
Background:
- Epilepsy in children and adolescents is frequently associated with emotional comorbidities.
- While research often focuses on affected children, the impact on family members, particularly mothers, warrants investigation.
Purpose of the Study:
- To investigate the association between childhood epilepsy and the prevalence of depression and anxiety in both patients and their mothers.
- To compare emotional health in children with epilepsy versus healthy controls and explore maternal psychological well-being.
Main Methods:
- A cross-sectional study involving 35 children/adolescents with epilepsy (ages 7-19) and 35 matched healthy controls.
- Standardized questionnaires (Kovac Child Depression Inventory, State-Trait Anxiety Inventory for Children, Beck Depression Inventory) were administered to participants and their mothers.
- Statistical analyses included Pearson correlations and Student's t tests to compare group scores and identify relationships.
Main Results:
- Children with epilepsy exhibited significantly higher depression scores (CDI) than controls (P<0.05).
- No significant differences in anxiety scores (STAIc) were found between children with epilepsy and controls (P>0.05).
- Mothers of children with epilepsy did not report higher depression (BDI) or anxiety (STAI) levels than mothers of controls (P>0.05), with no correlation observed between maternal and child scores.
Conclusions:
- Children and adolescents with epilepsy demonstrate a higher incidence of depressive symptoms compared to healthy peers.
- Anxiety symptoms in children with epilepsy were not significantly different from controls.
- Maternal mental health status does not appear to be directly correlated with the presence of epilepsy or its associated emotional symptoms in their children.
Objective:
Children with epilepsy have high rates of depression and anxiety. The majority of studies concentrate on the children with epilepsy, but the emotional impact of epilepsy on family members is of clinical concern. In this cross-sectional study we aimed to examine the association between epilepsy in childhood and adolescence, and anxiety and depression in these patients and their mothers.
Methods:
We studied 35 children and adolescents with seizures (age range, 7-19 years), 35 gender-matched healthy controls (age range, 8-17) who did not have any chronic medical illness, and mothers of these individuals (n=70) in a cross-sectional analysis. We administered the Kovac Child Depression Inventory (CDI) and State-Trait Anxiety Inventory for Children (STAIc) to the children. We administered the Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) to the mothers of these children. Pearson correlations were used to analyze dependence between variables, and Student's t test was used to compare mean values between test scores.
Results:
Patients with epilepsy had higher CDI scores (mean+/-SD, 12.48+/-6.35) than controls (9.31+/-5.11) (P<0.05), whereas the STAIc scores did not differ between cases (34.03+/-8.29) and controls (35.20+/-6.23) (P<0.05). Mothers of children with epilepsy did not have more depression or anxiety symptoms than mothers of children without epilepsy as measured by BDI and STAI scores (P>0.05). There was no correlation between mothers' scores and patients' or controls' scores.
Conclusions:
These results support findings from previous studies that children and adolescents with epilepsy have a higher frequency of depressive but not anxiety symptoms than the general population of healthy children and that this is independent of their mothers' symptoms.
Related Concept Videos
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Depression: Overview
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Electroconvulsive Therapy
Social Anxiety Disorder