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Updated: Aug 20, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Molecular characterization of fluconazole resistance in a case of Candida albicans ocular infection
Preeti Pancholi1, Steven Park, David Perlin
1Clinical Microbiology Laboratory, Department of Pathology, New York Presbyterian Hospital, Columbia University Medical Center, 622 West 168th St., CHS 3-326, New York, NY 10032, USA. prp9005@nyp.org
Abstract:
Ocular yeast infections in diabetics are a therapeutic challenge. Drug resistance and reduced azole susceptibility are major concerns. The case we describe characterizes a Candida albicans strain from a vitrectomy specimen that was susceptible to fluconazole by in vitro testing but recalcitrant to therapy. Molecular studies revealed transient overexpression of CDR1 and ERG11 mRNA in the presence of fluconazole that may have contributed to poor clinical response in this patient.

