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Aminophylline as an adjunct diuretic for neonates--a case series
Geraldine Yin Taeng Ng1, Emma Harriet Baker, Katharine Florence Mary Farrer
1Department of Neonatology, Neonatal Intensive Care Unit, St George's Hospital, Blackshaw Road, Tooting, London SW17 0RE, UK. drgytng@aol.com
Abstract:
Aminophylline is an adenosine receptor antagonist. Adult and paediatric studies have demonstrated a diuretic effect of aminophylline due to increased renal blood flow and the inhibition of solute reabsorption in various segments of the nephron. We report a case series of five infants with volume overload despite frusemide treatment. Aminophylline was successfully used as an adjunct diuretic with increased urine output and effective weight loss occurring in all five neonates following its introduction.
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