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Meningioma with eosinophilic granular inclusions

R T Alexander1, R E McLendon, T J Cummings

  • 1Duke University Medical Center, Durham, NC, USA. rusty4i@yahoo.com

Clinical Neuropathology
|December 9, 2004
PubMed

Insights

This study details a rare planum sphenoidale meningioma in a 66-year-old woman. The tumor cells contained unique intracytoplasmic eosinophilic inclusions with distinct ultrastructural and immunohistochemical properties.

Area of Science:

  • Neuropathology
  • Oncology

Background:

  • Meningiomas are tumors arising from the meninges.
  • Rare variants can exhibit eosinophilic inclusions with granular or granulofilamentous ultrastructure.

Observation:

  • A 66-year-old woman presented with a planum sphenoidale meningioma.
  • Histology revealed a well-differentiated meningioma with fascicles and whorls.
  • Tumor cells contained numerous round, intracytoplasmic eosinophilic inclusions.

Findings:

  • Inclusions were periodic acid Schiff-negative and Masson trichrome-positive.
  • Immunohistochemistry showed vimentin positivity and negativity for EMA, SMA, desmin, and collagen IV.
  • Ultrastructural analysis identified well-demarcated, non-membrane-bound, osmiophilic granular material.

Implications:

  • This case presents a meningioma with unique eosinophilic inclusions.
  • The distinct histochemical, immunohistochemical, and ultrastructural features differentiate it from previously reported cases.
  • Further research may elucidate the nature and origin of these inclusions.

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