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Related Experiment Videos

Protracted phencyclidine coma from an intestinal deposit.

J D Young1, L M Crapo

  • 1Department of Internal Medicine, Santa Clara Valley Medical Center, San Jose, Calif. 95128.

Archives of Internal Medicine
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

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A massive phencyclidine (PCP) overdose occurred when a patient swallowed a drug-filled bag. Persistent high PCP levels indicated ongoing absorption, resolving after the bag was naturally passed, suggesting early endoscopy for similar cases.

Area of Science:

  • Toxicology
  • Pharmacology
  • Emergency Medicine

Background:

  • Phencyclidine (PCP) is a dissociative anesthetic with high abuse potential.
  • PCP can be administered orally, intravenously, or via inhalation, leading to varied toxicity profiles.
  • Massive overdoses require understanding drug absorption and elimination dynamics.

Observation:

  • A patient presented with a massive phencyclidine overdose after ingesting a plastic bag containing the drug.
  • Serum phencyclidine levels remained persistently elevated for three weeks, suggesting a sustained internal source.
  • The drug bag was eventually passed rectally on hospital day 20.

Findings:

  • Following the passage of the drug-filled bag, serum phencyclidine levels declined consistent with known pharmacokinetics.

Related Experiment Videos

  • The patient experienced rapid recovery of neurologic function after the source of absorption was eliminated.
  • Persistently elevated drug levels in overdose cases warrant investigation for ongoing gastrointestinal drug absorption.

    • Implications:

    • This case highlights the importance of considering retained gastrointestinal drug packets in cases of prolonged phencyclidine toxicity.
    • Early endoscopic evaluation, including colonoscopy and esophagogastroduodenoscopy, is recommended to identify and remove such drug repositories.
    • Prompt identification and removal of internal drug packets can significantly improve patient outcomes in massive overdose scenarios.