Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acoustically modulated x-ray phase contrast imaging.

Theron J Hamilton1, Claude J Bailat, Christoph Rose-Petruck

  • 1Department of Chemistry, Brown University, Providence, RI 02912, USA.

Physics in Medicine and Biology
|December 9, 2004
PubMed
Summary

This study introduces a novel imaging technique combining ultrasound radiation pressure and phase contrast X-ray imaging. The method enhances visualization of small density changes in soft tissues by highlighting high-frequency features.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-photon chemistry of tetrahydrofuran in clathrate hydrates.

Physical chemistry chemical physics : PCCP·2024
Same author

Observation of Electric-Field-Induced Liberation of Guest Molecules from Clathrate Hydrate.

The journal of physical chemistry letters·2021
Same author

Generation of high amplitude compressions and rarefactions in a photoacoustically excited droplet.

Photoacoustics·2021
Same author

Heterodyned photoacoustic effect generated by irradiation of single particles by two laser beams modulated at different frequencies.

Ultrasonics·2020
Same author

Differential Infrared Pyrometry for Determination of Microkelvin Temperature Variations.

Analytical chemistry·2019
Same author

Emissivity determination using the photoacoustic effect.

Applied optics·2018

Area of Science:

  • Medical Imaging
  • Acoustics
  • Physics

Background:

  • Phase contrast X-ray imaging (PCXRI) offers enhanced sensitivity to small density variations compared to conventional radiography.
  • Ultrasound radiation pressure can induce measurable displacements in biological tissues.

Purpose of the Study:

  • To develop a novel imaging method using ultrasound radiation pressure to enhance PCXRI.
  • To create an acoustic contrast agent for improved soft tissue imaging.

Main Methods:

  • Utilizing intense ultrasound to generate radiation pressure and induce micro-displacements in biological samples.
  • Employing phase contrast X-ray imaging to capture images with and without the ultrasound field.
  • Subtracting images to isolate high-spatial-frequency features and suppress low-frequency background.

Related Experiment Videos

Main Results:

  • The developed technique produces an image proportional to the spatial derivative of the PCXRI in the ultrasound propagation direction.
  • The method effectively highlights small density changes in soft tissues, acting as an acoustic contrast agent.
  • Image subtraction removes low spatial frequencies, emphasizing high-frequency details.

Conclusions:

  • Combining ultrasound radiation pressure with PCXRI provides a powerful new tool for soft tissue imaging.
  • This acoustic contrast enhancement method improves the detection of subtle density variations.
  • The technique offers potential for advanced medical diagnostics and research.