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Related Experiment Videos

[The five-word test in memory deficiency].

R Mazzoleni1, J C Peeters, A Lakaye

  • 1Service de Neurologie et Clinique de la Mémoire, C.H.U. de Charleroi.

Revue Medicale De Bruxelles
|December 9, 2004
PubMed
Summary
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The 5-Word test, combined with the Mini-Mental State Examination (MMSE), effectively screens for Alzheimer's disease (AD) and vascular dementia at bedside. This reliable memory assessment tool improves diagnostic accuracy for early cognitive decline.

Area of Science:

  • Neurology
  • Cognitive Science
  • Geriatrics

Background:

  • Bedside memory tests are crucial for early cognitive decline detection.
  • The 5-Word test assesses free and cued selective recollection.
  • Existing diagnostic tools may require enhancement for improved accuracy.

Purpose of the Study:

  • To evaluate the reliability of the 5-Word test in Belgian French speakers.
  • To assess the diagnostic utility of the 5-Word test combined with the Mini-Mental State Examination (MMSE) for Alzheimer's disease (AD) and vascular dementia (VD).
  • To develop a logistic regression model for predicting AD and dementia probability.

Main Methods:

  • The 5-Word test was administered to five groups: normal subjects, depressive patients, AD patients, VD patients, and a validation cohort.

Related Experiment Videos

  • Data from the 5-Word test and MMSE were used in a logistic regression model.
  • Variance analysis assessed the impact of free and cued recall on immediate and delayed recall across four groups.

    • Main Results:

    • A significant third-order interaction (p < 0.001) was found between normal, AD, and VD groups.
    • The combined 5-Word test and MMSE model correctly classified 98% of normal subjects and 57 patients with AD (p < 0.001).
    • The 5-Word test significantly increased the sensitivity of the MMSE for early AD diagnosis.

    Conclusions:

    • The 5-Word test is a reliable, low-tech bedside tool for assessing memory.
    • Combining the 5-Word test with the MMSE offers good specificity for AD diagnosis.
    • This combined approach is valuable for screening populations with early cognitive and memory deficits, aiding in memory clinic referrals.