Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

13.4K
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
13.4K
Stereotype Content Model02:16

Stereotype Content Model

15.4K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.4K
Molecular Models02:00

Molecular Models

43.7K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.7K
The Bohr Model02:18

The Bohr Model

80.8K
Following the work of Ernest Rutherford and his colleagues in the early twentieth century, the picture of atoms consisting of tiny dense nuclei surrounded by lighter and even tinier electrons continually moving about the nucleus was well established. This picture was called the planetary model since it pictured the atom as a miniature “solar system” with the electrons orbiting the nucleus like planets orbiting the sun. The simplest atom is hydrogen, consisting of a single proton as the...
80.8K
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

7.1K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
7.1K
Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

312
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
312

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic analysis of CNS remyelination.

Current topics in microbiology and immunology·2008
Same author

Humoral autoimmunity as a mediator of CNS repair.

Trends in neurosciences·2002
Same author

Immunoglobulin-mediated CNS repair.

The Journal of allergy and clinical immunology·2001
Same author

Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same author

Drosophila nerve cord culture: a tool for studying neural development.

Journal of neuroscience methods·1999
Same author

Mutations in the Drosophila neuroglian cell adhesion molecule affect motor neuron pathfinding and peripheral nervous system patterning.

Journal of neurobiology·1997

Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
04:11

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Published on: October 27, 2023

1.3K

Contrasting murine models of MS.

A L A Nelson1, A J Bieber, M Rodriguez

  • 1Program in Molecular Neuroscience, Mayo Graduate School, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

International MS Journal
|December 9, 2004
PubMed
Summary

Animal models like EAE and TMEV are crucial for studying multiple sclerosis (MS). Analyzing these models aids in understanding MS and developing safer, more effective therapies.

Area of Science:

  • Neuroimmunology
  • Animal Models of Disease

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease.
  • Understanding MS pathophysiology is key to developing treatments.

Purpose of the Study:

  • To review the utility of current animal models for MS research.
  • To highlight how these models inform therapeutic development.

Main Methods:

  • Review of experimental autoimmune encephalomyelitis (EAE) model.
  • Review of Theiler's murine encephalomyelitis virus (TMEV) infection model.

Main Results:

  • Both EAE and TMEV models have contributed significantly to MS understanding.
  • These models facilitate the study of immune and inflammatory processes in MS.

More Related Videos

A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

6.6K
Phase Contrast and Differential Interference Contrast DIC Microscopy
06:49

Phase Contrast and Differential Interference Contrast DIC Microscopy

Published on: August 6, 2008

54.1K

Related Experiment Videos

Last Updated: Jan 31, 2026

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
04:11

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Published on: October 27, 2023

1.3K
A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

6.6K
Phase Contrast and Differential Interference Contrast DIC Microscopy
06:49

Phase Contrast and Differential Interference Contrast DIC Microscopy

Published on: August 6, 2008

54.1K

Conclusions:

  • Continued analysis of therapeutic successes and failures in these models is vital.
  • Optimizing animal models can lead to more targeted and safer MS treatments.