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Updated: Aug 20, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Immune-based therapies for prostate cancer
Douglas G McNeel1, Miroslav Malkovsky
1Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA. dm3@medicine.wisc.edu
Abstract:
Prostate cancer is a leading cause of cancer morbidity and mortality in the United States. Animal and clinical studies performed four decades ago suggested that immunological approaches might be useful for the treatment of prostate cancer. The wealth of information that has been learned over the last two decades has suggested many new directions to the immune-based therapy of prostate cancer, including passive and active immunotherapy approaches. The findings from current trials, and the likely combination of current immunotherapy approaches with conventional therapies, portends a hopeful future for the treatment of prostate cancer.
Insights
Immunotherapy offers a promising new avenue for treating prostate cancer, a major cause of death. Recent advancements in active and passive immunotherapy suggest a hopeful future when combined with traditional treatments.
Area of Science:
- Oncology
- Immunology
Background:
- Prostate cancer is a significant cause of morbidity and mortality in the United States.
- Early studies over four decades ago indicated potential benefits of immunological approaches for prostate cancer treatment.
Purpose of the Study:
- To explore advancements in immune-based therapy for prostate cancer.
- To review current immunotherapy approaches and their potential combination with conventional therapies.
Main Methods:
- Review of animal and clinical studies.
- Analysis of information gathered over the last two decades on immune-based therapy.
- Evaluation of current clinical trials and future treatment strategies.
Main Results:
- Immunological approaches have evolved significantly over the past two decades.
- Both passive and active immunotherapy strategies are being developed for prostate cancer.
- Current trials show promise, especially when immunotherapy is combined with conventional treatments.
Conclusions:
- The field of immune-based therapy for prostate cancer has advanced considerably.
- Combining immunotherapy with conventional therapies offers a hopeful outlook for improved patient outcomes.
- Further research and clinical trials are essential to fully realize the potential of immunotherapy in prostate cancer treatment.
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