Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

cDNA microarray gene expression analysis and toxicological phenotype for anticancer drug.

Gyoung-Jae Lee1, Wan-Seon Lee, Ki-Seon Jeon

  • 1Research Institute, Shin-Won Scientific Co., Ltd. Gyeonggi-do, South Korea.

The Journal of Veterinary Medical Science
|December 9, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic and metabolite diversity of Sundaland Heptapleurum (Araliaceae) insight into evolutionary and specialized metabolite.

BMC plant biology·2026
Same author

Multi-scale environmental drivers of heron and egret colony assemblages in Korea using self-organizing map clustering.

Scientific reports·2026
Same author

One-minute oscillometric vs. continuous arterial pressure monitoring for hypotension during anesthetic induction in low-risk patients: A randomized noninferiority trial.

Journal of clinical anesthesia·2026
Same author

First-in-human and multicenter phase I study of OSCA therapy for knee osteoarthritis.

Experimental & molecular medicine·2026
Same author

KBN2201 attenuates Aβ pathology and neuroinflammation while promoting neuroprotective and neurogenesis-related changes in a late-stage 5xFAD mouse model of Alzheimer's disease.

Neuropharmacology·2026
Same author

Potential Application of CAR-NK Cells as an <i>Ex Vivo</i> Therapy for T-cell-related Diseases.

Frontiers in bioscience (Landmark edition)·2026

Toxicogenomics uses gene expression to understand drug toxicity. This study compared gene patterns of paclitaxel and an oral form, revealing insights into anticancer activity and toxicity.

Area of Science:

  • Toxicogenomics
  • Genomics
  • Bioinformatics
  • Drug Discovery

Background:

  • Toxicogenomics merges genomics and toxicology to elucidate drug mechanisms.
  • Gene expression profiling aids in understanding drug toxicity and predicting new candidates.
  • The core hypothesis is that chemical-specific gene expression patterns reveal toxicological properties.

Purpose of the Study:

  • To compare gene expression patterns of paclitaxel and orally absorbable paclitaxel.
  • To gain genome-wide insights into the anticancer activity and toxicological phenotype of these drugs.

Main Methods:

  • Utilizing toxicogenomics principles.
  • Employing gene expression profiling technology.
  • Conducting cDNA microarray analysis on samples from exposed organisms.

Related Experiment Videos

Main Results:

  • Identified and compared distinct gene expression patterns between paclitaxel and its orally absorbable form.
  • Provided a genome-wide perspective on the molecular mechanisms underlying their anticancer effects and toxicity.

Conclusions:

  • Gene expression profiling is a powerful tool for understanding drug mechanisms.
  • This comparative analysis offers new possibilities for evaluating anticancer drug activity and toxicity.