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Updated: Aug 20, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Serum leptin elevation in obese women with PCOs: a continuing controversy
Hisham Ali Saleh1, Mohamed Amr El-Nwaem, Magdy Mamdouh El-Bordiny
1Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. hishamsaleh@link.net
Purpose:
To evaluate leptin levels in a sample of obese women with PCOS and compare the results with obese and non-obese control, to be ultimately correlated with BMI, and insulin sensitivity.
Methods:
Leptin and insulin assays by immuno-radiometric method, glucose assay by enzymatic colorimetric method.
Results:
Leptin levels were significantly different between obese and non-obese subjects, and were significantly different between insulin resistant and non-insulin resistant obese PCOS, but were not significantly different between obese non-insulin resistant PCOS, and obese controls.
Conclusions:
Body mass index and insulin resistance are the two main factors governing serum leptin levels.
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