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[Congenital disorders of hemostasis in children with Perthes disease]
Grzegorz Kandzierski1, Urszula Malek, Andrzej Gregosiewicz
1Katedra i Klinika Ortopedii Dzieciecej i Rehabilitacji, Akademia Medyczna im. F. Skubiszewskiego w Lublinie.
Insights
Congenital hemostasis disturbances are unlikely to cause Perthes disease. Most children with Perthes disease showed normal coagulation and fibrinolysis parameters, indicating other factors are likely involved.
Area of Science:
- Pediatric Orthopedics
- Hematology
- Coagulation Science
Context:
- Perthes disease is a childhood hip disorder of unknown etiology.
- Hemostasis and fibrinolysis play roles in vascular health and tissue repair.
- Assessing coagulation parameters in children with Perthes disease is crucial for understanding potential contributing factors.
Purpose:
- To evaluate coagulation and fibrinolysis parameters in children diagnosed with Perthes disease.
- To determine if congenital hemostasis disturbances are associated with the development of Perthes disease.
Summary:
- Twenty-five children with Perthes disease had their coagulation and fibrinolysis parameters assessed, including prothrombin time, partial thromboplastin time, fibrinogen, protein C system, Factor V Leiden, and Antithrombin III.
- Most parameters were normal in all patients.
- Prolonged prothrombin time was observed in three children, and an anomalous protein C system in one child.
Impact:
- The findings suggest that congenital hemostasis abnormalities are not the primary cause of Perthes disease in the majority of affected children.
- This research helps to narrow down the potential etiological factors of Perthes disease.
- Further research into other potential causes of Perthes disease is warranted.
Abstract:
The level of selected parameters of the coagulation system and fibrynolysis (prothrombin time, partial thromboplastin time, fibrinogen level, albumin C system, V Leiden factor and III antithrombin level) in 25 children who had been treated with Perthes disease was evaluated. In three children prolonged prothrombin time occurred; in one child anomalous protein C system was noted. The remaining parameters were normal in all children. The investigation results reveal that congenital disturbances of the haemostasis system were not the cause of Perthes disease in 24 children.
