Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth cone motility.

C Cypher1, P C Letourneau

  • 1Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis 55455.

Current Opinion in Cell Biology
|February 1, 1992
PubMed
Summary

Growth cone migration guides neuron development. Recent studies highlight the roles of cytoskeletal filaments, cell membranes, and specific neurite proteins in this crucial process.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuronal contact guidance in magnetically aligned fibrin gels: effect of variation in gel mechano-structural properties.

Biomaterials·2001
Same author

Neurotrophins and the dynamic regulation of the neuronal cytoskeleton.

Journal of neurobiology·2000
Same author

Stabilization of growing retinal axons by the combined signaling of nitric oxide and brain-derived neurotrophic factor.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2000
Same author

Embryonic neurons adapt to the inhibitory proteoglycan aggrecan by increasing integrin expression.

The Journal of neuroscience : the official journal of the Society for Neuroscience·1999
Same author

Guided neurite elongation and schwann cell invasion into magnetically aligned collagen in simulated peripheral nerve regeneration.

Experimental neurology·1999
Same author

Axon guidance: A balance of signals sets axons on the right track.

Current biology : CB·1999

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Neuronal development relies on precise growth cone migration for establishing connections.
  • Understanding the molecular mechanisms governing growth cone guidance is essential for developmental neuroscience.

Purpose of the Study:

  • To summarize recent advancements in understanding growth cone migration and pathfinding.
  • To elucidate the functional roles of cytoskeletal elements and cell membranes in growth cone dynamics.
  • To highlight the utility of antisense messenger RNAs (mRNAs) in investigating neurite protein functions.

Main Methods:

  • Review of recent scientific literature on growth cone migration.
  • Analysis of studies focusing on cytoskeletal dynamics and cell membrane properties.
  • Examination of research employing antisense mRNAs to probe neurite protein functions.

Main Results:

  • Key properties of cytoskeletal filaments and cell membranes critical for growth cone function have been identified.
  • Antisense mRNAs have emerged as a powerful tool for dissecting the roles of individual neurite proteins.

Conclusions:

  • Continued research into growth cone migration is vital for understanding neuronal development.
  • Specific molecular components, including cytoskeletal proteins and membrane dynamics, are key regulators of neuronal pathfinding.
  • Antisense mRNA technology offers a precise method for functional analysis of neurite proteins in vivo.

Related Experiment Videos