Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intermediate filament dynamics.

J E Eriksson1, P Opal, R D Goldman

  • 1Department of Cell, Molecular and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611-3008.

Current Opinion in Cell Biology
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adverse events among early caregivers' COVID-19 vaccination correlated inversely with intention to vaccinate their children.

Vaccine·2025
Same author

Willingness to vaccinate children against COVID-19 declined during the pandemic.

Vaccine·2023
Same author

Factors associated with unvaccinated caregivers who plan to vaccinate their children.

Preventive medicine·2022
Same author

A low-cost paper-based platform for fast and reliable screening of cellular interactions with materials.

Journal of materials chemistry. B·2020
Same author

Nanoparticles carrying fingolimod and methotrexate enables targeted induction of apoptosis and immobilization of invasive thyroid cancer.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2020
Same author

Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.

Neuroscience·2015

Intermediate filaments are not static; they continuously incorporate new subunits to maintain cellular structure. Post-translational modifications, like phosphorylation, are key to regulating their dynamic organization.

Area of Science:

  • Cell Biology
  • Cytoskeleton Dynamics

Background:

  • Intermediate filaments were traditionally viewed as static structural components of the cell.
  • Recent research suggests a more dynamic role for these cytoskeletal elements.

Purpose of the Study:

  • To investigate the dynamic nature of intermediate filaments.
  • To understand the mechanisms regulating intermediate filament organization and structure.

Main Methods:

  • Studies involved microinjection or gene transfection of exogenous intermediate filament proteins.
  • Analysis focused on subunit incorporation into existing filaments.

Main Results:

  • Demonstrated continuous incorporation of subunits into polymerized intermediate filaments.

Related Experiment Videos

  • Showed this incorporation is essential for maintaining normal cytoplasmic networks.
  • Identified phosphorylation as a critical post-translational regulator of filament dynamics.

    • Conclusions:

    • Intermediate filaments are dynamic structures, not static.
    • Continuous subunit addition is vital for maintaining functional intermediate filament networks.
    • Phosphorylation plays a significant role in regulating the dynamic organization and structure of intermediate filaments.