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Allylthiosulfinate: beta-cyclodextrin inclusion complex: preparation, characterization and microbiological activity
V Nikolic1, M Stankovic, A Kapor
1Faculty of Technology, University of Nish, Leskovac, Serbia and Montenegro. nvesna@yahoo.com
Die Pharmazie
|December 14, 2004
Summary
A novel allylthiosulfinate: beta-cyclodextrin inclusion complex demonstrates significant antimicrobial activity. This complex effectively inhibited the growth of tested fungi and bacteria, with notable efficacy against Candida albicans.
Area of Science:
- Medicinal Chemistry
- Microbiology
- Materials Science
Background:
- Allylthiosulfinates possess known biological activities.
- Beta-cyclodextrin is a well-established host molecule for drug delivery.
- Complexation can enhance the properties of bioactive compounds.
Purpose of the Study:
- To synthesize and characterize a novel allylthiosulfinate: beta-cyclodextrin inclusion complex.
- To evaluate the microbiological activity of the synthesized complex against various pathogens.
- To determine the susceptibility of different microorganisms to the complex.
Main Methods:
- Synthesis of the allylthiosulfinate: beta-cyclodextrin inclusion complex.
- Characterization using X-ray crystallography, IR spectroscopy, thermal analysis, and nuclear magnetic resonance (NMR).
- Microbiological assays to assess inhibition of fungal and bacterial growth.
Main Results:
- The allylthiosulfinate: beta-cyclodextrin inclusion complex was successfully synthesized and characterized.
- The complex exhibited inhibitory effects on all tested microorganisms at low concentrations.
- Candida albicans ATCC 10231 was the most susceptible, while Pseudomonas aeruginosa ATCC 9027 was the least susceptible.
Conclusions:
- The allylthiosulfinate: beta-cyclodextrin inclusion complex is a promising antimicrobial agent.
- Complexation with beta-cyclodextrin enhances the antimicrobial potential of allylthiosulfinates.
- Further research into this complex could lead to new therapeutic applications.