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Updated: Aug 20, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
Published on: September 4, 2017
Finding the maximum safe dose level for heteroscedastic data
Ajit C Tamhane1, Brent R Logan
1Departments of IE/MS and of Statistics, Northwestern University, Evanston, IL 60208, USA. ajit@iems.northwestern-edu
Abstract:
In this article we extend to the heteroscedastic setting the multiple stepwise test procedures proposed in Tamhane et al. [Tamhane. A. C., Dunnett, C. W., Green, J. W., Wetherington, J. F. (2001). Multiple test procedures for identifying a safe dose. J. Am. Statist. Assoc. 96:835-843] for finding the maximum safe dose. Toxicological data are often heteroscedastic; therefore, the extensions given herein should be highly useful in practice. Simulations are performed to study the Type I familywise error rate and power properties of the procedures. A real data example is given to illustrate the procedures.
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