Related Experiment Video
Updated: Aug 20, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
Pathophysiology of antiphospholipid antibodies
P G de Groot1, R H W M Derksen
1Department of Haematology, Room G03.647, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. ph.g.degroot@azu.nl
Abstract:
The presence of antiphospholipid antibodies in plasma is a risk factor for thromboembolic complications. In vitro, however, the same antibodies can prolong dotting times in coagulation assays, a classic marker for a bleeding tendency. For years this contradiction has puzzled many scientists. Recently new insights into the interaction between antiphospholipid antibodies and their main target, the protein beta-2-glycoprotein I, have opened new avenues for the understanding of the pathology of this syndrome.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Peripheral Artery Disease I: Introduction
Coronary Artery Disease II: Pathophysiology
Venous Thrombosis I: Introduction
Humoral Immune Responses
Myasthenia Gravis ll: Pathophysiology
