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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1)

Shawn J Stachel1, Craig A Coburn, Thomas G Steele

  • 1Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, West Point, Pennsylvania 19486, USA. shawn_stachel@merck.com

Journal of Medicinal Chemistry
|December 14, 2004
PubMed

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