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Updated: Jun 28, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
Protein interactions and fluctuations in a proteomic network using an elastic network model
Melik C Demirel1, Ozlem Keskin
1College of Engineering, Pennsylvania State University, University Park, PA 16802, USA. melikdemirel@psu.edu
Abstract:
A set of protein conformations are analyzed by normal mode analysis. An elastic network model is used to obtain fluctuation and cooperativity of residues with low amplitude fluctuations across different species. Slow modes that are associated with the function of proteins have common features among different protein structures. We show that the degree of flexibility of the protein is important for proteins to interact with other proteins and as the species gets more complex its proteins become more flexible. In the complex organism, higher cooperativity arises due to protein structure and connectivity.
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