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Related Experiment Videos

Update on genome completion and annotations: Protein Information Resource.

Cathy Wu1, Daniel W Nebert

  • 1Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC, USA.

Human Genomics
|December 14, 2004
PubMed
Summary

The Universal Protein Resource (UniProt) unifies major protein databases, enhancing protein annotation. This resource aids evolutionary studies and data integration for researchers.

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Area of Science:

  • Bioinformatics
  • Proteomics
  • Computational Biology

Background:

  • The Protein Information Resource (PIR) collaborated with the European Bioinformatics Institute (EBI) and Swiss Institute of Bioinformatics (SIB).
  • This collaboration led to the establishment of UniProt, the Universal Protein Resource.
  • UniProt integrates the PIR, Swiss-Prot, and TrEMBL protein databases.

Purpose of the Study:

  • To describe the UniProt resource and its integrated components.
  • To highlight the role of the Protein Information Resource (PIR) classification system (PIRSF) in protein annotation.
  • To introduce the iProClass database for data integration and associative studies.

Main Methods:

  • UniProt unifies data from PIR, Swiss-Prot, and TrEMBL.

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  • The PIRSF classification system organizes proteins into a network based on evolutionary relationships.
  • The iProClass database integrates UniProt data with over 50 other databases.

    • Main Results:

    • UniProt provides a unified and comprehensive resource for protein information.
    • The PIRSF system enables functional annotation and evolutionary analysis of proteins.
    • iProClass offers value-added descriptions and extensive cross-database links for UniProt proteins.

    Conclusions:

    • The PIR system facilitates consistent, rich, and accurate protein annotation.
    • UniProt, supported by PIRSF and iProClass, enhances protein research and data accessibility.
    • This unified resource benefits all investigators in the field of protein science.