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Updated: Aug 20, 2026
Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea,
Mário T Murakami1, Lisandra M Gava, Sandro P Zela
1Departamento de Física, IBILCE, Universidade Estadual Paulista, Cristóvão Colombo, 2265, Nazareth, 15054-000, São José do Rio Preto, SP, Brazil.
Abstract:
Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA(2) from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 degrees C. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a=49.05, b=63.84 and c=85.67 angstroms. Diffraction data was collected to 1.78 angstroms.
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