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Updated: Aug 20, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Molecular cytogenetic study of instability at 1q21 approximately q32 in adult acute lymphoblastic leukemia
Giorgina Specchia1, Francesco Albano, Luisa Anelli
1Hematology, University of Foggia, Foggia, Italy. emadhba@cimedoc.uniba.it
Abstract:
In the present paper, we report a molecular cytogenetic study of 1q abnormalities associated with t(8;14)(q24;q32) in an adult common B acute lymphoblastic leukemia case with FAB-L2 morphology. The use of appropriate molecular cytogenetic probes allowed us to detect 13 different subclones showing heterogeneous chromosome 1 abnormalities. A complex pattern of rearrangements consisting of translocations, duplications, and inversions was observed. Breakage-fusion-bridge cycle and jumping translocation are hypothesized to have been involved in generating the large number of aberrations we detected.

