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Related Concept Videos

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Coordination Number and Geometry02:57

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For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
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Lattice Centering and Coordination Number02:33

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The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
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Determining the Plane of Cell Division02:13

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Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
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Molecular Factors Affecting Cell Division01:27

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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
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Coordination Compounds and Nomenclature02:54

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In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
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Related Experiment Video

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Use of Drosophila S2 Cells for Live Imaging of Cell Division
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How cells coordinate growth and division.

Paul Jorgensen1, Mike Tyers

  • 1Department of Medical Genetics and Microbiology, University of Toronto, Toronto ON, Canada M5S 1A8. jorgensen@mshri.on.ca

Current Biology : CB
|December 14, 2004
PubMed
Summary

Cell size is crucial for cellular function and requires precise regulation. Recent genetic studies in Drosophila and yeast are beginning to unravel the complex molecular mechanisms controlling cell size homeostasis.

Area of Science:

  • Cell Biology
  • Genetics
  • Developmental Biology

Background:

  • Cell size is a fundamental property influencing cellular fitness and function.
  • Maintaining cell size homeostasis necessitates accurate duplication of cell mass before division.
  • Cell division timing is linked to achieving a critical cell size, particularly in yeast.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying cell size control.
  • To understand how cell growth and division are coordinated.
  • To gain genetic insight into cell size regulation, a historically challenging area.

Main Methods:

  • Utilizing genetic screens in Drosophila.
  • Employing functional genomics approaches in yeast.
  • Analyzing molecular and genetic pathways involved in cell size regulation.

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Main Results:

  • Recent genetic screens have provided new molecular insights into cell size control.
  • Functional genomics in yeast have shed light on mechanisms of cell size homeostasis.
  • These approaches are beginning to dissect the complex regulatory networks governing cell size.

Conclusions:

  • Advances in genetic and genomic tools are crucial for understanding cell size control.
  • The study of cell size regulation is progressing due to recent molecular discoveries.
  • Future research will likely build upon these findings to fully elucidate cell size mechanisms.