Related Experiment Videos
Anterior mediastinal nonseminomatous germ cell tumor with malignant transformation: a case report
Michael Michel1, Jerry W Pratt
1Division of Cardiothoracic Surgery, Keesler Medical Center, Keesler Air Force Base, Biloxi, MS 39534, USA. michael.michel@keesler.af.mil
Objective:
We report a case of a 21-year-old man who presented with the unusual symptoms of heart failure and was found to have an anterior mediastinal yolk sac tumor.
Methods:
A review of the literature using the Ovid search engine was performed.
Results:
The patient was treated with the current standard of neoadjuvant chemotherapy: bleomycin, etoposide, and cisplatin (BEP) with marked reduction in tumor size, followed by en bloc surgical resection. The final pathology revealed teratoma with malignant change: chondrosarcoma, adenocarcinoma, and poorly differentiated sarcoma.
Conclusions:
This is a rare initial presentation of an anterior mediastinal germ-cell tumor with treatment consisting of neoadjuvant therapy and surgical resection. In addition, we present the adverse and extremely rare malignant degeneration of this tumor.