Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolutionary perspective on annexin calcium-binding domains.

R O Morgan1, S Martin-Almedina, J M Iglesias

  • 1Department of Biochemistry and Molecular Biology, Edificio Santiago Gascon, Faculty of Medicine, University of Oviedo, 33006 Oviedo, Spain. romorgan@bioquimica.uniovi.es

Biochimica Et Biophysica Acta
|December 14, 2004
PubMed
Summary

Molecular analysis reveals structural variations in annexin gene superfamilies, impacting calcium binding and ion channel function. These findings suggest complex mechanisms controlling annexin membrane interactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applied and environmental microbiology·2018
Same author

Green alder (Alnus viridis) encroachment shapes microbial communities in subalpine soils and impacts its bacterial or fungal symbionts differently.

Environmental microbiology·2017
Same author

Host-Feeding Sources and Infection With Trypanosoma cruzi of Triatoma infestans and Triatoma eratyrusiformis (Hemiptera: Reduviidae) From the Calchaqui Valleys in Northwestern Argentina.

Journal of medical entomology·2016
Same author

Comparison of Modern Methods for Analyzing Repeated Measures Data With Missing Values.

Multivariate behavioral research·2016
Same author

Impact of timing of adjuvant chemotherapy initiation and completion after surgery on racial disparities in survival among women with breast cancer.

Medical oncology (Northwood, London, England)·2013
Same author

Delusional parasitosis of body orifices - a cultural variant?

Indian journal of psychiatry·2011

Area of Science:

  • Molecular biology
  • Evolutionary biology
  • Biochemistry

Background:

  • Annexins are calcium-dependent phospholipid-binding proteins crucial for membrane interactions and ion channel function.
  • Structural variations in annexin calcium-binding domains can affect their biological activity.

Purpose of the Study:

  • To investigate the evolutionary origin and structural variation of calcium-binding domains within the annexin gene superfamily.
  • To understand the functional implications of these variations on membrane targeting and ion channel activity.

Main Methods:

  • Molecular systematic analysis of the annexin gene superfamily.
  • Identification and characterization of structural variations in calcium-binding domains.
  • Comparative analysis of annexin sequences across different phyla.

Related Experiment Videos

Main Results:

  • Approximately 36% of annexin repeat domains show loss of type two calcium-binding sites.
  • A novel K/H/RGD motif was identified in 11% of annexin domains, conserved across phyla via convergent evolution.
  • Specific annexin clades, including yeast and amphioxus, exhibit unique structural modifications impacting calcium-binding and channel regulation.

Conclusions:

  • Selective erosion of calcium-binding sites and the presence of alternate ligands are common in annexins.
  • These variations suggest a more complex regulatory mechanism for annexin membrane interaction and calcium channel operation than previously understood.