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Growth factor receptor expression in orbital lymphangioma: possible therapeutic implications
Bita Esmaeli1, Victor G Prieto, Russell Gonnering
1Ophthalmology Section, Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA. besmaeli@mdanderson.org
Objective:
To examine the expression of molecules targeted by imatinib mesylate (STI571;Gleevec) and epidermal growth factor receptor (EGFR) inhibitors in orbital lymphangiomas.
Design:
Retrospective observational case series.
Participants:
Six patients with orbital lymphangioma treated at four institutions between March 2000 and December 2002.
Methods:
Tissue specimens and medical records from six patients were collected. Immunohistochemical analysis was performed using antibodies against c-kit and platelet-derived growth factor receptor (PDGFR) alpha and beta and EGFR tyrosine kinase.
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