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Related Experiment Videos

Single embryo transfer in clinical practice.

Christel Hydén-Granskog1, Aila Tiitinen

  • 1Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland. christel.hyden-granskog@hus.fi

Human Fertility (Cambridge, England)
|December 14, 2004
PubMed
Summary

Elective single embryo transfer (eSET) significantly reduces multiple pregnancies in assisted reproduction. A robust cryopreservation program is crucial for high cumulative delivery rates without increasing multiple births.

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Area of Science:

  • Reproductive Medicine
  • Obstetrics & Gynecology
  • Clinical Embryology

Background:

  • Multiple pregnancies are a primary cause of adverse outcomes in assisted reproductive technology (ART).
  • Elective single embryo transfer (eSET) and embryo cryopreservation are key strategies to mitigate this risk.

Purpose of the Study:

  • To evaluate the effectiveness of an eSET program in reducing multiple pregnancy rates.
  • To assess the feasibility of implementing eSET as a primary transfer policy.
  • To determine the impact of eSET on overall pregnancy and delivery rates.

Main Methods:

  • Implementation of an eSET program starting in 1997, with a shift to single embryo transfer as the primary option in 2000.
  • Analysis of transfer policies in 2003, noting 60% of fresh transfers and 66% of frozen transfers were single embryo transfers.

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  • Monitoring of multiple pregnancy rates, overall pregnancy rates, and delivery rates within the program.

    • Main Results:

    • The eSET program successfully decreased the multiple pregnancy rate to approximately 7%.
    • Acceptable overall pregnancy and delivery rates were maintained.
    • The adoption of eSET in daily practice was demonstrated as feasible.
    • Increased use of single embryo transfer in Finland has led to a reduction in multiple births.

    Conclusions:

    • Elective single embryo transfer is an effective strategy for reducing multiple pregnancies in assisted reproduction.
    • A well-established cryopreservation program is essential for achieving high cumulative delivery rates while avoiding multiple gestations.
    • eSET programs can be successfully integrated into routine clinical practice, improving ART outcomes.