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In silico fine-mapping: narrowing disease-associated loci by intergenomics
Pablo Serrano-Fernández1, Saleh M Ibrahim, Dirk Koczan
1Institute of Immunology, University of Rostock, Schillingallee 70, D-18057 Rostock, Germany. serrano@pzr.uni-rostock.de
Bioinformatics (Oxford, England)
|December 14, 2004
Abstract
Unlabelled:
Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was created to identify intergenomic consensuses to fine map QTLs and SLs in silico and select particularly promising candidate genes for such traits. Furthermore, this approach offers an empirical evaluation of animal models for their applicability to the study of human traits.
Availability:
http://qtl.pzr.uni-rostock.de/qtlmix.php
Contact:
serrano@pzr.uni-rostock.de.