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Related Experiment Videos

HESAS: HERVs Expression and Structure Analysis System.

Tae-Hyung Kim1, Yeo-Jin Jeon, Woo-Yeon Kim

  • 1PBBRC, Interdisciplinary Research Program of Bioinformatics, College of Natural Sciences, Pusan National University, Busan 609-735, Korea.

Bioinformatics (Oxford, England)
|December 14, 2004
PubMed
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The HESAS database aids in understanding human endogenous retroviruses (HERVs) and their impact on human gene expression. It catalogs HERV elements within human genes, detailing their structural and expression characteristics.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections integrated into the primate genome.
  • Understanding HERVs is crucial for deciphering their potential roles in gene regulation and human diseases.
  • Previous studies have identified HERVs but lacked a comprehensive system for analyzing their expression and structural impact on host genes.

Purpose of the Study:

  • To develop a specialized database, HESAS (HERVs Expression and Structure Analysis System), for analyzing human endogenous retroviruses.
  • To investigate the influence of HERVs on the expression of human functional genes.
  • To provide a resource for researchers studying the evolutionary and functional significance of HERVs in the human genome.

Main Methods:

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  • Exon-based expressed sequence tag (EST) clustering was employed.
  • Partial HERV structures were reconstructed, accounting for mutations accumulated during primate evolution.
  • HERV expression types were classified based on the presence of splicing, transcriptional start, and polyadenylation signal sites.

Main Results:

  • The HESAS database integrates information on 26,981 human genes with exon-intron structures.
  • HERV elements have been identified within 17,317 of these genes.
  • A significant link between HERV elements and the expression of 898 human genes was established.

Conclusions:

  • The HESAS database provides a valuable resource for understanding the impact of HERVs on human gene expression.
  • The analysis reveals that HERV elements are widespread in the human genome and can influence gene expression.
  • This system facilitates further research into the functional roles of HERVs in human biology and evolution.