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Long-term challenges in growth hormone treatment
1Department of Endocrinology, Hospital Universitario Virgen del Rocio, Hospital General, Sevilla, Spain. alfonso.leal.sspa@juntadeandalucia.es
Hormone Research
|December 14, 2004
Summary
Growth hormone deficiency (GHD) negatively impacts physical and mental health, reducing quality of life. GH replacement therapy significantly improves GHD symptoms, enhancing well-being and physical function.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Clinical Medicine
Background:
- Growth hormone deficiency (GHD) is biochemically defined by a peak GH concentration below 5 microg/l post-hypoglycaemia.
- GHD syndrome encompasses physical and psychological symptoms like increased adiposity, reduced bone density, mood disturbances, and decreased quality of life.
Purpose of the Study:
- To discuss the long-term consequences of GHD.
- To review the effects of GH replacement therapy on GHD-associated symptoms and quality of life.
Main Methods:
- Literature review of clinical trials and studies on GHD and GH replacement therapy.
- Analysis of reported outcomes related to body composition, cardiovascular function, exercise capacity, muscle strength, and psychological well-being.
Main Results:
- GH replacement therapy demonstrated improvements in lean body mass, reduced adipose tissue, enhanced left ventricular systolic function, and increased exercise capacity.
- Significant improvements were observed in muscle strength, well-being, and vitality following GH treatment.
- Conflicting results exist regarding the impact of GH therapy on insulin sensitivity in GHD patients.
Conclusions:
- GH replacement therapy offers substantial benefits for GHD patients, improving physical and psychological health.
- Further research is needed to clarify the effects of GH therapy on insulin sensitivity.
- Addressing GHD can lead to a significant enhancement in patients' overall quality of life.